STEREOCHEMICAL ANALYSIS IN 22-MEMBERED MACROLIDESpdf BASED ON MOLECULAR MODELING

  • BELAIDI S Unit of computational chemistry, VPRS Laboratory, University of Ouargla, 30000, Ouargla, Algeria.
  • DIBI A Laboratory of chemistry and environment chemistry, University of Batna, 05000, Batna, Algeria.
  • OMARI M Department of chemistry, University of Biskra, B.P. 145, 07000, Biskra, Algeria.
  • LANEZ T Unit of computational chemistry, VPRS Laboratory, University of Ouargla, 30000, Ouargla, Algeria.

Abstract

Conformational analysis of macrolides with 22-ring membered has been carried out using molecular modeling (molecular mechanics and molecular dynamics). The results indicate that each investigated macrocycles present eight types of preferential conformations. They result of the combination of two systems diene and ester a,b-unsaturated. A high conformational mobility of no complexed macrocycles (22) was obtained. In presence of tricarbonyliron, the number of the privileged conformations was reduced.

Published
2006-01-01
How to Cite
S, B., A, D., M, O., & T, L. (2006). STEREOCHEMICAL ANALYSIS IN 22-MEMBERED MACROLIDESpdf BASED ON MOLECULAR MODELING. Annals of Science and Technology, 1(1), 4. Retrieved from https://journals.univ-ouargla.dz/index.php/AST/article/view/169
Issue
Vol 1 No 1 (2006): volume 1 numéro 1 2006
Section
Articles