Isolation of Cardenolide glycosides from Pergularia tomentosa.L and their Antioxidant activities

  • Zohra BABAAMER Chemistry Department, University of Jordan, Amman, Jordan, Department of Industrial Chemistry, University of Ghardaia, Ghardaia 47 000, Algeria
  • Musa ABU ZARGA Chemistry Department, University of Jordan, Amman, Jordan
  • Nesren GHAZI AL-ABDALLAT Biology Department, University of Jordan, Amman, Jordan.
  • Lakhdar SAKHRI Univ Ouargla, Fac. des Sciences Appliquées, Dépt. de Génie des Procédés, Ouargla 30 000, Algeria
Keywords: P. tomentosa.L, Asclepiadaceae, cardenolide, 2D-NMR, antioxidant activities

Abstract

Continuing our investigations on plants belonging to the Asclepiadaceae family, five known cardenolide glycosides (1-5), have been isolated from the aerial parts of P. tomentosa.L. The structures of these isolated compounds were identified by spectroscopic data as Uscharidin 1 which is isolated for the first time from Pergularia tomentosa.L, Calactin 2, 12 -hydroxycalotropin 3, 6’-hydroxycalactin 4, and Galakinoside 5. The structures were elucidated by chemical and spectroscopic methods (2D-NMR, IR, and MS) and by comparison with the authentic samples (literature data). In addition, antioxidant activities of three cardenolide, the highest scavenging activity of DPPH, was observed in 2 (IC50= 1953 μg/ ml), followed by 4 (IC50= 3384 μg/ ml), and 3 (IC50= 3410 μg/ ml).

Published
2014-10-15
How to Cite
BABAAMER, Z., ABU ZARGA, M., GHAZI AL-ABDALLAT, N., & SAKHRI, L. (2014). Isolation of Cardenolide glycosides from Pergularia tomentosa.L and their Antioxidant activities. Annals of Science and Technology, 6(2), 7. Retrieved from https://journals.univ-ouargla.dz/index.php/AST/article/view/381
Issue
Vol 6 No 2 (2014): volume 6 numéro 2 2014
Section
Articles