POLYSACCHARIDES AND ASCORBIC ACID CONTENT AND THE EFFECT OF AQUEOUS EXTRACT OF Portulaca oleraceaIN HIGH-FAT DIET-INDUCED OBESITY, DYSLIPIDEMIA AND LIVER DAMAGE IN ALBINO WISTAR RATS

  • DEROUICHE Samir Department of Cellular and Molecular Biology, Faculty of natural scienceand life, University of El Oued, El-Oued 39000, Algeria
  • ABBAS Kaouther Department of Cellular and Molecular Biology, Faculty of natural scienceand life, University of El Oued, El-Oued 39000, Algeria
  • DJERMOUNE Manal Department of Cellular and Molecular Biology, Faculty of natural scienceand life, University of El Oued, El-Oued 39000, Algeria
Keywords: Portulaca oleracea, ortulaca oleracea, Polysaccharide, High Fat Diet, Obesity, liver damage

Abstract

-The aim of the present study was to evaluate the hypolipidemic and antioxidant properties of aqueous extracts of Portulaca oleraceain experimental obese rats. Twenty four (24) apparently healthy male Wistar rats were grouped into four groups (6 rats in each): normal, Obese, Obese + Atorvastatine (100 mg kg-1 day-1) and Obese + P. oleracea(400 mg kg-1 day-1.) groups. All rats except those in the control group were made dyslipidemic using a high-fat cafeteria food. All drug administration was done orally for a period of four weeks. Administration of P. oleraceareduced the levels of TG (26.99%), TC (10.91%) and LDL (16.41%), which were elevated by obesity. Analysis of the effect of P. oleraceaon antioxidant liver, revealed that P. oleracea potentially regulates lipid peroxides and protects organs from oxidation-associated damage. The markers of liver damage such as SGPT and SGOT levels that were elevated (p<0.05) by HFD were also reduced on P. oleraceatreatment. In conclusion, this study has shown the aqueous leaf extracts of P.olercea, lowers blood glucose and lipid profile levels and is a beneficial effect against the development of obesity and a good antioxidant and hepatoprotective property

 

POLYSACCHARIDES AND ASCORBIC ACID CONTENT AND THE EFFECT OF AQUEOUS EXTRACT OF Portulaca oleraceaIN HIGH-FAT DIET-INDUCED OBESITY, DYSLIPIDEMIA AND LIVER DAMAGE IN ALBINO WISTAR RATS
Published
2018-12-27